|
KMID : 1140420170260030197
|
|
Journal of Obesity & Metabolic Syndrome
2017 Volume.26 No. 3 p.197 ~ p.203
|
|
|
The Cut-off Value of Blood Mercury Concentration in Relation to Insulin Resistance
|
|
Lee Seok-Hoon
Choi Beom-Hee
Park Soo-Jung
Kim Young-Sang
Joo Nam-Seok
|
|
|
Abstract
|
|
|
Background: Increased blood mercury concentration is associated with inflammation, and chronic inflammation can cause insulin resistance. We examined the cut-off value of blood mercury in relation to an increased score on the homeostasis model assessment for insulin resistance (HOMA-IR).
Methods: We used data from the Korean National Health and Nutrition Examination Survey (2008-2010). Relevant data from 5,184 subjects (2,523 men and 2,661 women) were analyzed cross-sectionally. General linear analysis was performed to evaluate the relationship between HOMA-IR score and blood mercury concentration. In addition, we determined the cut-off value of blood mercury concentration in relation to increased HOMA-IR score (〉 2.34) using an ROC curve.
Results: The mean value of blood mercury concentration in men and women was 5.88 μg/L and 4.11 μg/L, respectively. In men, comparing to the first quartile, HOMA-IR score increased significantly in the third and fourth blood mercury quartiles. In women, however, the increase in HOMA-IR score was not significant. The cut-off value that best represented the association between increased HOMA-IR score and blood mercury concentration in men was found to be 4.71 μg/L.
Conclusion: Blood mercury concentration was associated with increased HOMA-IR score in men, and the cut-off value of blood mercury concentration that was correlated with increased HOMA-IR score was around 4.71 μg/L.
|
|
|
KEYWORD
|
|
|
Mercury, HOMA-IR, Insulin resistance, Cut-off value, Diabetes
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|